2018卵巢癌患者凋亡抑制蛋白Survivin表达与血清糖类抗原153检测的临

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　　【摘要】目的:探讨卵巢癌患者凋亡抑制蛋白Survivin表达与血清糖类抗原153(CA153)检测的临床意义及二者的关系。 方法:分别应用免疫组织化学法和化学发光免疫法检测65例卵巢癌中Survivin表达情况与血清CA153的水平，进行相关性分析。 结果:卵巢癌患者治疗前血清CA153浓度为(35.6±11.3)U/ml，治疗后为(11.8±3.6)U/ml，差异有统计学意义(t=2.915, P0.05);Survivin阳性表达患者中腋窝淋巴结转移率为68.0%(24/50),Survivin阴性表达患者腋窝淋巴结转移率为6.7%(1/15)，差异有统计学意义(χ2=17.465，P http://
　　【关键词】卵巢癌;凋亡抑制蛋白;Survivin;血清糖类抗原153;转移
　　【中图分类号】R737.31【文献标识码】A【文章编号】1008-6455（2011）10-0023-02Expression of survivin and level of serum CA153 in patients with breast carcinoma
　　Zhang Qingchun
　　【Abstract】Objective:To investigate the expression of survivin protein and the level of serum CA153 in patients with breast carcinoma. Methods:The expression of survivin and the level of serum CA153 were examined respectively by immunohistochemical method and chemiluminescent immunoassay in 65 patients with breast cancer. Correlation between survivin expression and other pathological variables of breast cancer was determined by Chi-square test, and the Spearman rank correlation test was used for analysis of survivin and CA153. Results:In breast cancer patients, the level of serum CA153 was significantly higher before treatment than after treatment (t=2.915, P0.05). The incidence of lymph node metastasis in patients with survivin expression was significantly higher than that in those without expression (68.0 % vs 6.7%, χ2 =17.465, P