[摘要] 目的 评价在前列地尔、甲钴胺联合治疗糖尿病周围神经病变（DPN）的疗效基础上，加用α-硫辛酸治疗的差异对比。方法 该院于2015年2月―2017年1月选取41例DPN患者，随机分为两组，对照组予以前列地尔注射液10 μg静脉推注，1次/d，?B续14 d，甲钴胺片500 mg，3次/d，1片/次，连续服用8周。治疗组在上述基础上，予以加用α-硫辛酸600 mg静滴，1次/d，周期14 d。观察治疗前后两组在MNSI评分、NSS评分、神经传导速度上的差异。 结果 治疗过程中，最终有效例数为对照组23例，治疗组18例，两组在基线上差异无统计学意义，治疗组的总有效率明显高于对照组（88.9% vs 56.5%），药物治疗后，两组在MNSI评分、NSS评分、神经传导速度较干预前均改善（P http://
[关键词] 糖尿病周围神经病变；α-硫辛酸；前列地尔；甲钴胺
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）07（b）-0011-03
Observation on Curative Effect of α-lipoic Acid， Alprostadil Combined with Mecobalamine in Treatment of Diabetic Neuropathy
YANG Yi-qing
Diabetes Center， Nanjing Xuanwu Hospital， Nanjing， Jiangsu Province， 210018 China
[Abstract] Objective To evaluate the curative effect of α-lipoic acid， alprostadil combined with mecobalamine in treatment of diabetic neuropathy. Methods 41 cases of DPN patients from February 2015 to January 2017 were selected and randomly divided into two groups， the control group adopted the intravenous injection of 10 μg alprostadil once a day for the consecutive 14 d and 500 mg mecobalamin tablets three times a day， a tablet once for the consecutive 8 weeks， and the treatment group adopted the intravenous injection of 600 mg α-lipoic acid once a day for 14 d on the basis of the control group， and the differences in the MNSI score， NSS score and nerve conduction velocity were compared before and after treatment. Results In the end， 23 cases in the control group and 18 cases in the treatment group were effective， and the difference in the baseline between the two groups was not statistically significant， and the total effective rate in the treatment group was obviously higher than that in the control group， （88.9% vs 56.5%）， after the drug treatment， the MNSI score， NSS score and nerve conduction velocity of the two groups were improved compared with those before intervention（P
发表于 2018-8-17 22:59:30