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中图分类号：R541.4 文献标 识码：A 文章编号：1009_816X(2011)06_0430_03
http://
DOI:10.3969/j.issn.1009_816X.2011.06.06Clinical Characteristics of Patients with Diffuse Coronary Heart Dise ase. Wu Mei_cui, Lin Zu_jin, Lin mei_e. Department of Cardiology, Tai zhou Central Hospital, Zhejiang 31800，China
［Abstract］ Objective To analyze the clinical characteristics o f patients with diffuse coronary heart disease. Methods A total of 454 patients with angiograp hicly confirmed coronary artery disease were retrospectively analyzed, based upo n the coronery disease characteristics of angiography. These patients were divid ed as group I (277 patients with diffuse coronery artery disease),group II (277 patients with nondiffuse coronery artery disease). The clinical documents, labor atory examination data and coronary angiographies results were compared between group I and group II patients. Results Compared to group II, the patients of g roup I had higher rates of diabetes (40.5% vs. 27.3%，P统计学处理：采用SPSS13.0软件包进行统计学分析，计量资料采用（x－±s）表示，两组间比较应用两独立样本t检验 。由于甘油三酯（triglyceride，TG）、脂蛋白a（lipoprotein_a，Lpa）、肌酐（Creatin ine Cr）为非正态分布，行对数转换后进行上述检验；计数资料采用卡方检验。P＜0 .05表示差异有统计学意义。
2 结果
两组在年龄、性别、高血压、高血脂、吸烟等方面无显著差异。但冠状动脉弥漫病变患者组 中2型糖尿病患者比例明显升高（40.53% vs 27.31%，P参考文献
［1］ACC/AHA Task Force. Guidelines for percutaneous transluminal coron ary angiography. A report of the American College of Cardiology/American Heart A ssociation Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Subcommittee on Percutaneous Transluminal Coronary Angioplasty)［J ］. J Am Coll Cardiol,1988,12(2):529-545.
［2］Burke AP, Kolodgie FD, Zieske A, et al. Morphologic Findings of Coronary At herosclerotic Plaquesin Diabetics A Postmortem Study［J］. Arterioscler Thromb Vasc Biol,2004,24(7):1266-1271.
［3］Natali A, Vichi S, Landi P, et al. Coronary atherosclerosis in Type II dia betes: angiographic findings and clinical outcome［J］. Diabetologia,2000,43(5): 632-641.
［4］邬美翠，陆林，吴立群，等.冠心病合并2型糖尿病冠状动脉造影特点分析［J］.上海 交通大学学报（医学版），2008,28（9）：1196-1197.
［5］Chen SN, Cilingiroglu M, Todd J, et al. Candidate genetic analysis of plasma high_density lipoprotein_cholesterol and severity of coronary atherosclerosis［J］. BMC Med Genet，2009，10:111.
［6］Navab M, Reddy ST, Van Lenten BJ, et al.HDL and cardiovascular disease: ath erogenic and atheroprotective mechanisms［J］. Nat Rev Cardiol,2011,8(4):222-232 .
［7］Walldius G, Jungner I. The apo B/apo A_I ratio: a strong, new risk factor f or cardiovascular disease and a target for lipidlowering therapy_a review of the evidence［J］. J Intern Med,2006，259(5):493-519.
［8］Sniderman AD, Junger I, Holme I, et al.Errors that result from the TC/HDL C ratio rather than the apo B/apo A_I ratio to identify the lipoprotein_related r isk of vascular disease［J］. J Intern Med,2006，259(5):455-461.
［9］Khadem_Ansari MH, Rasmi Y, Rahimi_Pour A, et al.The association between s erum apolipoprotein A_I and apolipoprotein B and the severity of angiographical coronary artery disease［J］. Singapore Med J，2009,50(6):610-613.
［10］Raos V, Strujic BJ. Dyslipoproteinemia and coronary disease［J］. Angiolog y，2002,53(5):557-562. |
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发表于 2018-8-16 10:25:58