2018彩色多普勒超声对类风湿性关节炎腕关节病变的应用价值
[摘要] 目的 探讨彩色多普勒超声对类风湿性关节炎腕关节病变的应用价值。 方法 选取在我院就诊的类风湿性关节炎患者共50例作为观察组,选择同期在我院健康体检人员50例为对照组。两组均接受彩色多普勒超声检查腕关节,观察并比较两组关节腔滑膜结构及滑膜内血流情况的差异。 结果 观察组患者的腕关节滑膜厚度明显大于对照组,差异有统计学意义(P http://[关键词] 类风湿性关节炎;腕关节病变;彩色多普勒超声;应用价值
[中图分类号] R445.1;R593.22 [文献标识码] B [文章编号] 1673-9701(2017)33-0102-04
Objective To evaluate the application value of color Doppler ultrasonography in the treatment of rheumatoid arthritis wrist lesions. Methods A total of 50 patients with rheumatoid arthritis who were admitted to our hospital were selected as the observation group. 50 healthy subjects who received physical examination during the same period of time were selected as the control group. Both groups were given color Doppler ultrasound for the examination of the wrist, and the differences of synovial membrane structure and synovial blood flow between the two groups were observed and compared. Results The thickness of synovial membrane of the wrist joint in the observation group was significantly higher than that in the control group, and the difference was statistically significant(P 1资料与方法
1.1一般资料
选取2016年1月~2017年1月期间在我院就诊的类风湿性关节炎患者共50例为观察组。纳入标准:符合1987年美国类风湿病学会制定的类风湿性关节炎诊断标准。排除标准:(1)腕关节外伤或手术史;(2)长期服用激素类药物。选择同期在我院健康体检人员50例为对照组。两组在年龄分布、性别构成等方面比较差异不明显(P>0.05),具有可比性。见表1。
1.2检查方法
两组均使用彩色多普勒超声检查腕关节,彩色多普勒超声仪器使用Vivid 7超声诊断仪器(美国GE公司),超声探头选择7.5 MHz高频超声探头,检查模式选择关节模式。所有被检查者均取仰卧位或坐位,手臂伸直,充分暴露腕关节,使用灰阶超声模式观察并记录腕关节滑膜情况,包括关节腔有无积液、关节面是否光滑、骨质有无破坏,并在滑膜最厚处检测滑膜厚度。采用彩色多普勒超声模式检测腕关节滑膜内血流情况,观察滑膜内血流信号,嘱患者平静呼吸,对患者滑膜动脉血流进行取样,取样框宽度选择2~3 mm,取样线与血管夹角小于30°,根据血流频谱测量阻力指数(RI)。采用相同方法检测对侧腕关节,所有记录数值均测量3次,取平均值为最终测量结果。观察两组关节腔滑膜情况,并同时检测两组腕关节滑膜内血流情况。
1.3观察指标
1.3.1 腕关节滑膜情况 包括滑膜厚度、滑膜有无增厚、关节腔有无积液、骨质有无破坏。其中滑膜厚度≥3 mm为滑膜增厚。
1.3.2 腕关节滑膜血流信号分级 0级:滑膜内未见血流信号;Ⅰ级:滑膜内可见1~2处点状血流信号;Ⅱ级:滑膜内见较多血流信号,呈短条状,小于滑膜面50%;Ⅲ级:滑膜内可见多处血流信号,呈树枝状或网状,超过滑膜面50%。其中血流信号丰富=Ⅱ级+Ⅲ级。
1.3.3腕关节滑膜动脉RI检测 对患者滑膜动脉血流进行取样,取样框宽度选择2~3 mm,取样线与血管夹角小于30°,根据血流频谱测量滑膜动脉RI。
1.4统计学方法
采用SPSS18.0 for windows软件对资料进行统计学分析处理,计量资料以均数±标准差(x±s)表示,组间比较用t检验,计数资料采用χ2检验,以P参考文献]
Takase K,Ohno S,Takeno M,et al.Simultaneous evaluation of long lasting knee synovitis in patients undergoing arthroplasty by power Doppler ultrasonography and contrast-enhanced MR in comparison with histopathology.Clin Exp Rheumatol,2012,30(1):85-92. 李?@园,臧国礼,赵雅萍. 彩色多普勒超声联合超声造影对类风湿性关节炎腕关节病变的临床价值. 中国医药导报,2016,13(34):126-129.
Hoving JL,Buchbinder R,Hall S,et al. A comparison of magnetic resonanceimaging,sonography,and radiography of the hand in patients with rheumatoid arthritis. J Rhenmaiol,2004,31(7):663-675.
Navalho M,Resende C,Rodngues AM,et al. Bilateral evaluation of the hand and wrist in untreated early inflamm-atory arthntis:a comparative study of ultrasonography and magnetic resonance imaging. Rheumatology,2013,40:1282-1292.
Klanser A,Frauscher F,Sehirmer M,et al. The value of contrast-enhanced color Doppler ultrasound in the detection of vascularization of finger joints in patients with rheumatoid arthritis. Arthritis Rheum,2002,46(3):647-653.
Scire CA,Montecucco C,Cadullo V,et al. Ultmsonographie evaluation of joint involvement in early rheumatoid arthritis inelinical remission:Power Doppler signal predies short-term relapse. Rheumatology,2009,48(9):1092-1097.
Varsamidis K,Vamidou E,Tjetjis V,et al.Doppler sonography in assessing disease activity in rheumatoid arthritis. Ultrasound Med Biol,2005,31(6):739-743.
Backhaus TM,Ohrndorf S,Kellner H,et al.The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy. Ann Rheum Dis,2013,72(7):1163-1169.
Nguyen H,Ruyssen-Witrand A,Gandjbakhch F,et a1. Prevalence of ultrasound―detected residual synovitis and risk of relapse and structural progression in rheumatoid arthritis patients in clinical remission:A systematic review and meta-analysis. Rheumatology,2014,53(11):2110-2118.
Vlad V,Berghea F,lagnocco A,et al.Inter&intra-observer reliability of grading ultrasound videoclips with hand pathology in rheumatoid arthritis by using non-sophisticated internet tools(LUMINA study). Med Uhrason,2014,16(1):32-36.
陈红菊,程大伟,张新颖. 高频超声在类风湿性关节炎腕关节早期病变中的诊断价值. 中国实用医药,2017,12(8):64-65.
Saleem B,Brown AK,Keen H,et al.Should imaging be a component of rheumatoid arthritis remission criteria? A comparison between traditional and modifed composite remission scores and imaging assessments. Ann Rheum Dis,2011,70(5):792-798.
Haavardshohm EA,Lie E,Lillegraven S. Should modem imaging be part of remission criteria in rheumatoid aarthritis?.Best Pract Res Clin Rheumatol,2012,26(6):767-785.
(收稿日期:2017-09-13)
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